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American Society of Microbiology ABMM Sample Questions:

1. A research laboratory is investigating the mechanisms of antiviral drug resistance. They are studying a herpes simplex virus strain that has developed resistance to acyclovir. The MOST common mechanism of acyclovir resistance in HSV involves mutations in the gene encoding:

A) Viral thymidine kinase
B) Viral glycoprotein D
C) Viral DNA polymerase
D) Viral protease

2. An immunocompromised patient develops a disseminated fungal infection. Blood cultures are consistently negative. However, a serum beta-D-glucan assay is markedly elevated. Tissue biopsy reveals the presence of hyaline, septate hyphae with dichotomous branching. The MOST likely causative organism is:

A) Cryptococcus neoformans
B) Mucor species
C) Aspergillus fumigatus
D) Rhizopus species

3. A previously healthy 28-year-old female develops a severe, watery diarrhea after attending a picnic where she consumed potato salad that had been left unrefrigerated for several hours. Stool culture reveals numerous Gram-positive bacilli. Further biochemical testing shows the organism is beta-hemolytic on blood agar and produces a heat-stable enterotoxin. The MOST likely causative agent is:

A) Vibrio cholerae
B) Staphylococcus aureus
C) Clostridium difficile
D) Bacillus cereus

4. A clinical microbiology laboratory encounters a Gram-negative bacillus isolated from a bloodstream infection. The isolate exhibits resistance to multiple antibiotics, including carbapenems. Further phenotypic testing reveals the production of a metallo-beta-lactamase (MBL). Which of the following antibiotic combinations might still retain activity against this isolate?

A) Ceftazidime-avibactam
B) Aztreonam
C) Piperacillin-tazobactam
D) Aztreonam-avibactam

5. A patient develops a febrile illness with a diffuse petechial rash after a camping trip. Serological testing reveals a four-fold rise in antibody titer to Rickettsia rickettsii. The vector responsible for transmitting this organism is a:

A) Tick
B) Louse
C) Flea
D) Mosquito

Solutions: