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American Society of Microbiology ABMM Exam Syllabus Topics:

American Society of Microbiology ABMM Sample Questions:

1. A patient with a history of intravenous drug use develops a fever and new heart murmur. Blood cultures are positive for Gram-positive cocci that are catalase-positive and coagulase-positive. The MOST likely complication of this infection is:

A) Reactive arthritis
B) Septic arthritis
C) Glomerulonephritis
D) Embolic stroke

2. Staphylococcus epidermidis, a common cause of healthcare-associated infections, forms biofilms on medical devices. The production of polysaccharide intercellular adhesin (PIA) is a key factor in biofilm maturation.
The expression of PIA is primarily regulated by:

A) Horizontal gene transfer of the ica operon.
B) The icaADBC operon, whose expression is influenced by environmental cues.
C) The stringent response pathway activated during nutrient limitation.
D) A two-component regulatory system involving AgrA and AgrC.

3. A microbiology laboratory receives a wound swab from a patient with a chronic, non-healing ulcer. Culture yields a Gram-positive, branching filamentous bacterium that is partially acid-fast. The MOST likely genus is:

A) Streptomyces
B) Mycobacterium
C) Actinomyces
D) Nocardia

4. During a primary infection with Epstein-Barr virus (EBV), the virus establishes latency in B lymphocytes.
The transition from lytic to latent infection is tightly regulated by viral gene expression. Which of the following viral proteins is crucial for the establishment and maintenance of EBV latency and is a key target in EBV-associated lymphomas?

A) Glycoprotein gp350
B) Viral capsid antigen (VCA)
C) Epstein-Barr nuclear antigen 1 (EBNA1)
D) Early antigen (EA)

5. A patient with cystic fibrosis experiences a pulmonary exacerbation. Sputum culture grows a mucoid strain of Pseudomonas aeruginosa. The mucoid phenotype is primarily due to the overproduction of:

A) Exotoxin A
B) Elastase
C) Pyocyanin
D) Alginate

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